Haneui Bae

Postdoctoral Research Associate (Department of Biochemistry)

Ph.D. (Molecular and Cellular Biology, Harvard University, 2020)

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Haneui received her B.A. from Amherst College studying Neuroscience. At Harvard University, she received her Ph.D. in Molecular and Cellular Biology, studying the molecular mechanisms of visual critical period plasticity. After graduating she decided to experience biomedical research in industry and joined a small biotech start-up in Cambridge called Tevard Biosciences, which works on developing tRNA therapies for rare genetic disorders. She moved to Champaign-Urbana in 2024 and started her work as a postdoctoral research associate in the Kalsotra lab.

Current Research

Haneui is interested in RNA-dominant diseases and RNA therapeutics. Currently she is working on studying Myotonic Dystrophy Type 1 (DM1), the most common form of adult-onset muscular dystrophy caused by trinucleotide repeat expansion in the 3’UTR of DMPK. DMPK is ubiquitously expressed and can affect all tissue types. She is investigating the molecular mechanisms of the disease and potential therapeutic targets in the liver and heart.
 

Outside the lab

 

In her free time, Haneui likes to dabble in creative crafts, like crocheting small stuffed animals for family and friends, designing t-shirt or departmental retreat logos, and laser printing art onto wood panels. She also likes to bake bread and cakes, hike, kayak, and indoor rock climb.

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Publication

  • Mavashov, A., Brusel, M., Liu, J., Woytowicz, V., Bae, H., Chen, Y.-H., Dani, V.S., Cardenal-Muñoz, E., Spinosa, V., Aibar, J.Á., and Rubinstein, M. (2023) Heat-induced seizures, premature mortality, and hyperactivity in a novel Scn1a nonsense model for Dravet syndrome. Front. Cell. Neurosci. 17:1149391. doi: 10.3389/fncel.2023.1149391
  • Bae, H., Hensch, T. (2023). Deficiency in neprilysin causes laminar impairments in the visual cortex. bioRxiv. doi: 10.1101/2023.03.05.531118
  • Bae, H., Coller, J. (2022). Codon optimality-mediated mRNA degradation: Linking translational elongation to mRNA stability. Mol Cell, 82, 1467–1476. doi: 10.1016/j.molcel.2022.03.032
  • Sigal, Y., Bae, H., Bogart, L., Hensch, T., Zhuang, X. (2019). Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging. PNAS, 116(14), 201817222. doi: 10.1073/pnas.1817222116
  • Bae, H., Chen, S., Roche, J. P., Ai, M., Wu, C., DiAntonio, A., Graf, E. R. (2016). Rab3-GEF controls active zone development at the Drosophila neuromuscular junction. eNeuro, 3(2), ENEURO-0031. doi: 10.1523/ENEURO.0031-16.2016