publications
- Altered drug metabolism and increased susceptibility to fatty liver disease in an inducible liver-specific
mouse model of myotonic dystrophy.
Dewald ZL, Chembazhi UV, Gupta A, Kalsotra A
bioRxiv [link] - Cell delivery agent as a drug. A multitarget agent delivers an antisense oligonucleotide for synergistic activity in myotonic dystrophy type 1.
Li K§, Chembazhi UV§, Kreuger SE, Dewald Z, Chen J, Bai Y, Kim D, Kocheril PA, Chen J, Kalsotra A*, Zimmerman SC*
Nature Communications, In Revision (2023) §denotes equal authors, *denotes co-corresponding authors - NK cell expansion requires HuR and mediates innate immune control of solid tumors and long-term virus infection.
Piersma S§, Bangru S§, Yoon J, Liu TW, Yang L, Plougastel-Douglas B, Kalsotra A*, Yokoyama WM*
Journal of Experimental Medicine (2023) §denotes equal authors; *co-senior authors [link] - PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression.
Chembazhi UV§, Tung WS§, Hwang H§, Wang Y, Lalwani A, Nguyen KL, Bangru S, Yee D, Chin K, Yang J, Kalsotra A*, Mei W*
Nucleic Acids Research (2023) §denotes equal authors, *denotes co-corresponding authors [link] - Splicing factor SRSF1 deficiency in the liver causes NASH-like pathology and cell death.
Arif W, Mathur B, Saikali MF, Chembazhi UV, Toohill K, Song YJ, Hao Q, Karimi S, Blue SM, Yee BA, Van Nostrand EL, Bangru S, Guzman G, Yeo GW, Prasanth KV, Anakk S, Cummins C, Kalsotra A
Nature Communications (2023) [link] - Cellular and molecular profiles of larval and adult Xenopus corneal epithelia resolved at the single-cell level.
Sonam S*, Bangru S*, Perry KJ, Chembazhi UV, Kalsotra A§, Henry JJ§
Developmental Biology (2022) *denotes equal authors, §denotes co-corresponding authors [link] - Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver.
Chembazhi UV*, Bangru S*, Hernaez M, Kalsotra A
Genome Research (2021) *denotes equal authors [link]
• News & View article from Nature Reviews Gastroenterology & Hepatology (Michalopoulos, 2021)
• Press coverage - Aberrant expression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy.
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubber ER, Hedhli J, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A
Developmental Cell (2020) [link]
• Press coverage - Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A*, Diehl AM*
Journal of Clinical Investigation (2020) *denotes co-corresponding authors [link] - Intrinsically cell-penetrating multivalent and multi-targeting ligands for Myotonic Dystrophy 1.
Lee J, Bai Y, Chembazhi UV, Peng S, Yum K, Luu LM, Hagler LD, Serrano JF, Chang HYE, Kalsotra A*, Zimmerman SC*
Proceedings of National Academy of Sciences (2019) *denotes co-corresponding authors [link]
• Highlighted by Myotonic Dystrophy Foundation - Cell-type specific polysome profiling from mammalian tissues.
Seimetz J, Arif W, Bangru S, Hernaez M, Kalsotra A
Methods (2019) [link] - Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration.
Bangru S*, Arif W*, Seimetz J, Bhate A, Chen J, Rashan EH, Carstens RP, Anakk S, and Kalsotra A
Nature Structural & Molecular Biology (2018) *denotes equal authors [link]
• Covered by the Naked Scientists Podcast
• Highlighted by Visible Embryo, Health24 News, and Fight Aging
• Press coverage - Poly(A) tail length regulates PABPC1 expression to tune translation in the heart.
Chorghade S*, Seimetz J*, Emmons RS, Yang J, Bresson SM, De Lisio M, Parise G, Conrad NK, Kalsotra A
eLIFE (2017) *denotes equal authors [link]
• Featured as the cover article.
• Commentary by Gray and Gray
• Highlighted by Nature Reviews Cardiology
• Press coverage - ESRP2 controls adult splicing program in hepatocytes to support postnatal liver maturation.
Bhate A*, Parker DJ*, Bebee TW, Ahn J, Arif W, Rashan EH, Chorghade S, Chau A, Lee JH, Anakk S, Carstens RP, Xiao X, Kalsotra A
Nature Communications (2015) *denotes equal authors [link]
• Highlighted by Healio and Genetic Engineering & Biotechnology News
• Press coverage
- Excess bile acid increase after partial hepatectomy in constitutive androstane receptor knockout mice drives regeneration.
Zhou W, Chembazhi UV, Huang J, Bangru S, Dean AE, Kalsotra A, Rudnick DA, Anakk S
In Review (2023) - Novel oxysterol Ester mobilization pathway protects against atherosclerosis.
Goo YH, Ayyappan JP, Bangru S, Saha PK, Lydic TA, Kalsotra A, Paul A
Proceedings of National Academy of Sciences USA, In Revision (2023) - SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes.
Peng J, Serrano G, Traniello IM, Calleja-Cervantes ME, Chembazhi UV, Bangru S, Ezponda T, Rodriguez-Madoz JR,
Kalsotra A, Prosper F, Ochoa I, Hernaez M.
Communications Biology (2022) [link] - Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver.
Mathur B, Shajahan A, Arif W, Chen Q, Hand NJ, Abramowitz LK, Schoonjans K, Rader DJ, Kalsotra A, Hanover JA, Azadi P, Anakk S
Science Advances (2021) [link] - Unbiased proteomic screening identifies a novel role for the E3 ubiquitin ligase Nedd4-2 in translational
suppression during ER stress.
Eagleman DE, Zhu J, Liu DC, Seimetz J, Kalsotra A, Tsai NP
Journal of Neurochemistry (2020) [link] - Antagonism between Splicing and Microprocessor complex Dictates the Serum-induced Processing of lncMIRHG
for Efficient Cell Cycle Re-entry.
Sun Q, Hao Q, Lin YC, Song, YJ, Bangru S, Arif W, Tripathi V, Zhang Y, Cho JH, Freier SM, Jenkins LM, Ma J, Yoon JH,
Kalsotra A, Lal A, Prasanth, SG, Prasanth KV.
RNA (2020) [link] - Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis.
Mathur B, Arif W, Patton M, Faiyaz R, Liu J, Yeh J, Harpavat S, Schoonjans C, Kalsotra A, Wheatley AM, Anakk S
JHEP Reports (2020) [link] - Effect of PFOA on DNA Methylation and Alternative Splicing in Mouse Liver.
Wen Y, Chen J, Li J, Arif W, Kalsotra A, Irudayaraj J
Toxicology Letters (2020) [link] - Complementary oligonucleotide conjugated multi-color carbon dots for intracellular recognition of biological events.
Srivastava I, Misra SK, Bangru S, Boateng K, Soares JANT, Schwartz-Duval AS, Kalsotra A, Pan D
ACS Applied Materials & Interfaces (2020) [link] - Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.
Skariah G, Seimetz J, Norsworthy M, Lannom MC, Kenny PJ, Elrakhawy M, Forsthoefel C, Drnevich J, Kalsotra A, Ceman S
BMC biology (2017) [link] - Maternal Dead-end 1 promotes translation of nanos1 by binding the eIF3 complex.
Aguero T, Jin Z, Chorghade S, Kalsotra A, King ML, Yang J
Development (2017) [link] - Mdm2 mediates FMRP-and Gp1 mGluR-dependent protein translation and neural network activity.
Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H, Tsai NP
Human molecular genetics (2017) [link] - Uncovering RNA binding proteins associated with age and gender during liver maturation.
Chaturvedi P, Neelamraju Y, Arif W, Kalsotra A, Janga SC
Scientific reports (2015) [link]
- Function and regulation of mRNA 3′-end diversity in health and disease.
Natua S, Zhang B, Kalsotra A
In Review (2023) - Emerging Roles of RNA-Binding Proteins in Fatty Liver Disease.
Adesanya O§, Das D§, Kalsotra A
BioEssays, In Review (2023) §denotes equal authors - The discovery, function, and regulation of epithelial splicing regulatory proteins.
Derham JM, Kalsotra A
Biochemical Society Transactions (2023) [link] - Cellular and molecular basis of liver regeneration.
Bangru S, Kalsotra A
Seminars in Cell & Developmental Biology (2020) [link] - Deregulation of RNA metabolism in microsatellite expansion diseases.
Misra C, Lin F, Kalsotra A
Advances Neurobiology (2018) [link] - RNA modifications and structures cooperate to guide RNA-protein interactions.
Lewis CJ, Pan T, Kalsotra A
Nature Reviews Molecular Cell biology (2017) [link] - Myotonic dystrophy: disease repeat range, penetrance, age of onset, and relationship between repaet size and phenotypes.
Yum K, Wang ET, Kalsotra A
Current opinions in Genetics & Development (2017) [link]
• Highlighted by Myotonic Dystrophy Foundation - Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism.
Arif W, Datar G, Kalsotra A
Biochimica et Biophysica Acta (BBA) (2017) [link] - Advances in analyzing RNA diversity in eukaryotic transcriptomes: peering through the omics lens.
Bangru S, Kalsotra A
F1000Research (2016) [link] - Developmental insights into the pathology and therapeutic strategies for DM1: back to the basics.
Chau A, Kalsotra A
Developmental Dynamics (2015) [link]